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Cardiac
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Home inotropic therapy in children

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Comparative costs of home positive inotropic infusion versus in-hospital care in patients awaiting cardiac transplantation

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Home inotropic therapy in advanced heart failure: cost analysis and clinical outcomes

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A prospective study of continuous intravenous milrinone therapy for status IB patients awaiting heart transplant at home

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Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure
 

Constipation
bulletPolyethylene Glycol and Electrolytes Helpful in Constipated Children
bullet Constipation management in palliative care: a survey of practices in the United kingdom
 

Mucositis & Sialorrhea

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Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis

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The assessment and implementation of mouth care in palliative care: a review

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EPERC Fast Facts and Concept #130; Oral Mucositis: Prevention and Treatment

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Mucositis - Chemotherapy Problems and Solutions

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Palifermin Effective for Oral Mucositis From Chemotherapy or Radiotherapy (Medscape 2005)

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Chemotherapy and Hematopoietic Stem Cell Transplantation Patients Management of Mucositis

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Questions and Answers on Palifermin (Keratinocyte Growth Factor)

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Palifermin for Oral Mucositis after Intensive Therapy for Hematologic Cancers

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A Biological Approach to Mucositis

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Clinical Trials in Supportive Care: Cancer Treatment-Related Mucositis (pdf)

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Gelclair
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Gelclair is a prescription-only, bioadherent oral gel indicated for the management/relief of pain associated with oral mucositis.
Gelclair adheres to and coats the inside of the mouth, acting as a liquid bandage. It coats exposed nerve endings, thereby relieving the pain of mucositis. Through its ability to relieve pain, Gelclair can also enable patients to eat and drink more easily.

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Current Developments in Treating Chemotherapy-Related Oral Mucositis
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(from Clinical Advances in Hematology-Oncology)

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Interventions for preventing oral mucositis for patients with cancer receiving treatment (Cochrane Review)

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Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy

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Comparative efficacy of patient-controlled administration of morphine, hydromorphone, or sufentanil for the treatment of oral mucositis pain following bone marrow transplantation

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Palliative Oral Care

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Topical ketamine in the treatment of mucositis pain
 

Nausea & Vomiting
bullet Use of a prophylactic antiemetic with morphine in acute pain: randomised controlled trial
bullet Responsiveness of life-threatening refractory emesis to gabapentin-scopolamine therapy following posterior fossa surgery
bullet The use of motion sickness bands to control nausea and vomiting in a group of hospice patients
bullet Comparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in children. Eur J Anaesthesiol, October 1, 2003; 20(10): 831-5
bullet Maternal inheritance in cyclic vomiting syndrome with neuromuscular disease
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Randomized double-blind study of the Reliefband as an adjunct to standard antiemetics in patients receiving moderately-high to highly emetogenic chemotherapy

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Cannabinoids in the Treatment of Symptoms in Cancer and AIDS

bullet Development and validation of the pediatric nausea assessment tool for use in children receiving antineoplastic agents
bulletTreatment of Nausea - A Review
Neurologic
bulletChannelopathies: A Review
Nutrition
bulletArtificial Nutrition and Hydration for the Terminally Ill: A Reasoned Approach
bullet Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study
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Bridging the continuum: nutrition support in palliative and hospice care

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Artificial Nutrition and Hydration

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Should Immunonutrition Become Routine in Critically Ill Patients? A Systematic Review
bulletConclusion  Immunonutrition may decrease infectious complication rates but it is not associated with an overall mortality advantage. However, the treatment effect varies depending on the intervention, the patient population, and the methodological quality of the study.
bulletJAMA. 2001;286:944-953

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The Role of Tube Feeding and Total Parenteral Nutrition in Advanced Illness American College of Surgeons (pdf)

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The Paradox of Hydration in Advanced Terminal Illness American College of Surgeons (pdf)

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Non-Oral Hydration in Palliative Care

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Effects of parenteral hydration in terminally ill cancer patients: a preliminary study

Respiratory
bullet Management of Dyspnea
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Nebulized Opioids for Dyspnea
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This information is based on the treatment of adults. One may wish to consider the use of this concept in the treatment of children.

bulletManagement of Dyspnea at the End of Life: Relief for Patients and Surgeons American College of Surgeons (pdf)
bullet A randomized, controlled trial of 1 week of continuous positive airway pressure treatment on quality of life
bulletHiccups
Sedation, Sleep & Awareness Disorders
bulletSedation in Mechanically Ventilated Patients
bulletNightmares
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The prevalence, key causes and management of insomnia in palliative care patients
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"Uncontrolled physical symptoms, most often pain (15 patients), were the commonest cause of insomnia"

bulletPharmacologic Management of Delirium; Update on Newer Agents

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Last modified: May 04, 2008